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Cancer Vaccine IFx-Hu2.0 Confers Immune Priming Effect in Previously Treated MCC and CSCC
IBI322 Shows Early Antitumor Efficacy in PD-1/PD-L1–Resistant Classical Hodgkin Lymphoma

Cancer Vaccine IFx-Hu2.0 Confers Immune Priming Effect in Previously Treated MCC and CSCC

The novel personalized cancer vaccine IFx-Hu2.0 was found to be safe and well tolerated with weekly dosing in patients with checkpoint inhibitor–resistant cutaneous squamous cell carcinoma (CSCC) a...

IBI322 Shows Early Antitumor Efficacy in PD-1/PD-L1–Resistant Classical Hodgkin Lymphoma

Single-agent IBI322 elicited responses with favorable safety in patients with classical Hodgkin lymphoma that had become resistant to anti–PD-1/PD-L1 therapy, according to data from a phase 1 trial...

GVAX Cancer Vaccine Plus Nivolumab and Urelumab Elicits Early Efficacy in Pancreatic Adenocarcinoma

Treatment with the GVAX pancreatic cancer vaccine plus nivolumab (Opdivo) and urelumab increased the presence of intratumoral activated cytotoxic T cells and showed early signs of efficacy in patie...

BAT8006 Elicits Disease Control, Safety in Advanced Ovarian Cancer and Other Solid Tumors

Treatment with the folate receptor–α (FRα) antibody-drug conjugate BAT8006 led to responses with a manageable safety profile in patients with advanced solid tumors, including ovarian cancer, breast...

Molecular Subtyping and Surgical Sequencing Broaden Immunotherapy Applications in RCC

Future advances in renal cell carcinoma (RCC) management hinge on better defined molecular selection and treatment sequencing, according to Tian Zhang, MD, who noted that the ongoing phase 2 OPTIC ...

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NK T-Cell Agonist Under Investigation in Combination With Pembrolizumab in Melanoma and NSCLC

The natural killer T-cell agonist IMM60 may overcome resistance to PD-1 inhibitors when combined with immunotherapy in patients with melanoma and non–small cell lung cancer.Nicholas Coupe, MBBS, Ph...

Dr. Ehrhardt on Factors Associated with Late Mortality in Survivors of Childhood Cancer

Matthew J. Ehrhardt, MD, MS, discusses the link between modifiable chronic health conditions and social determinants of health with late mortality for survivors of childhood cancer.PauseMuteCurrent...

Brain Volume Patterns Vary Across Psychiatric Disorders

A large brain imaging study of adults with six different psychiatric illnesses shows that heterogeneity in regional gray matter volume deviations is a general feature of psychiatric illness, but th...

Pig Kidneys Show 'Life-Sustaining' Function in Human

A pair of genetically modified pig kidneys filtered blood and produced urine for 7 days after being transplanted into a brain-dead patient ― marking another important step toward opening up a new...

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